Bone Pendant
Oral Cancer Patients Is Expected By Cytokine Treatment
Cytokines in patients with oral cancer is expected to be bio-treated. May 12, world-class academic journals “PloSone” (“U.S. Public Library of Science 22 integrated”) published an important topic in our scientists results?? To silkworm bioreactor, cytokines active protein finally found oral absorption of the “green channel” in order to achieve oral absorption of cytokines. This achievement marks the application of cytokines in cancer treatment outlook for major breakthroughs.
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By the Shanghai Institute of Biochemistry and Cell Institute Professor Wu Xiangfu and Zhejiang University PhD supervisor Professor Zhang Yaozhou led, by the Zhejiang University and Zhejiang Institute of Technology and Zhejiang University and the Silkworm Bioreactor and Key Laboratory of biological drugs more than 10 joint research team composed of experts, after 20 years of research, to make an announcement this important discovery. It is learned that this achievement has been the national drug clinical trials permits, full access to the second, Phase III clinical trial, expected to be China and the world’s first oral drug cytokines tumor treatment.
Tied for first on paper, the main research topic group members, Zhejiang Institute of Technology Associate Professor College of the Lvzheng Bing explained, the public through the silkworm bioreactor for the production of cytokine granulocyte – macrophage colony-stimulating factor (GM- CSF), is an activity with the body’s own proteins, with activation of human tumor immunity, and then kill and control involved in tumor cells, promote proliferation of human bone marrow hematopoietic stem cells, treatment and prevention of chemotherapy induced bone marrow suppression, neutropenia and thrombocytopenia clinical disorders such effect.
Unlike in the past, this is the first time, GM-CSF used in clinical capsule formulations. Prior to injection, as biological agents, the main problem is the clinical side effects, treatment is not convenient, it is difficult long-term administration. “Oral protein drug research field of biological medicine is seen as the focus. So far, no real sense foreign protein oral drug. Most of the cellular factors and proteins including GM-CSF, interferon and interleukin factors can only be through the muscle or subcutaneous injection. If these drugs in the clinic can be effectively absorbed through the oral, bio-pharmaceutical industry will be significant reforms. “issue, Chief Scientific Adviser, CAS Shanghai Institute of Biochemistry and Cell, Professor Liu Fellows said the new wall.
Lvzheng Bing, associate professor explained that the greatest contribution of this study is that oral absorption of cytokines found an effective way. If the oral route was used in the past, cytokines, digestive enzymes break down because of loss of activity, which has been difficult to break through oral protein. Using silkworm as a bioreactor, the silkworm contains a variety of protease inhibitors and a large number of lipids and the formation of GM-CSF “lipid-coated” to protect GM-CSF “hide” than digestive enzymes to help through the intestinal wall, into the human blood. In the rat study, using high power microscope can observe this process. In human clinical trials in healthy volunteers, oral cytokine in the serum using mass spectrometry identified specific peaks, the peaks proved to be derived from the oral activity of GM-CSF peptide, this powerful evidence of oral GM-CSF can the body absorb and retain biological activity. In clinical trials so far, this approach has not found any Adverse reactions , Has been “the State Technological Invention Award” and the many national patents.
Liu Xinyuan Fellow pointed out that biological Medicine Development, the cytokines and immune cells to the basis, improving the body’s anti-tumor immunity, remove or control cancer cells without harming normal cells, “green” bio-therapy, can significantly improve cancer cure rates, patient survival and life quality, will be following the surgery, radiotherapy and chemotherapy in the fourth mainstream cancer therapy treatment. Clinical expert group
topic, chairman of Shanghai Cancer Institute, Shanghai Changzheng Hospital, director of oncology, said Professor Wang Jiejun, this important discovery to the clinical significance of positive reality. Currently, cancer chemotherapy patients with bone marrow suppression caused only by way of injection of cytokines to treatment, clinical side effects, oral administration of GM-CSF will be safe and effective in patients with new options.
About the Author
I am China Computer Parts writer, reports some information about carved bone pendants , multi strand clasps.
carving a New Zealand maori whale bone pendant
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